Vitamin B1 Hcl(Thiamine Hydrochloride)

1.What is Vitamin B1 Hcl?

Thiamine Hydrochloride is vitamin B1. Thiamine hydrochloride is the hydrochloride salt of thiamine, also known as thiamine hydrochloride. It is a water-soluble vitamin purified by humans, primarily existing in the form of vitamin B1.

Thiamine hydrochloride is found in rice bran, germ, yeast, eggs, green leaves, and legumes. As a water-soluble vitamin B1, it can help treat diseases caused by vitamin B1 deficiency. It serves as a nutritional supplement that participates in carbohydrate metabolism within the body and plays a vital role in maintaining normal nerve conduction, as well as the proper functioning of the heart and digestive system.

Specification:BP2024/USP2024
Test Item	Specification	Result
Appearance	white or almost white crystalline powder or colourless crystals	White crystalline powder
Identification	(1)should be positive reaction	(1)positive reaction  (2)Consistent with the
	(2)Consistent with the reference IR spectra	reference IR spectra
Appearance of solution	clear,not more intense than Y7	clear,not more intense than Y7
Heavy metals(as Pb)	NMT20ppm	<20ppm
Pb	≤2.0ppm	<0.05ppm
As	≤2.0ppm	<0.05ppm
Cd	≤1.0ppm	<1.0ppm
Hg	≤0.1ppm	<0.1ppm
Sulphates	NMT300ppm	<300ppm
Limit of nitrate	No brown ring	No brown ring
Water	NMT5.0%	2.3%
Residue on ignition	NMT0.1%	0.06%
Absorbance of solution Residual Solvents	NMT0.025	0.013
—Methanol	NMT0.3%	<0.3%
—Ethanol	NMT0.5%	<0.5%
Related substances(Disregard limit 0.05%)
—Impurity A	NMT0.15%	0.076%
—Impurity B	NMT0.3%	0.002%
—Impurity C	NMT0.15%	0.002%
—Any impurity	NMT0.1%	0.06%
一Total impurities	NMT0.5%	0.24%
Microbials
Total aerobie microbial count	NMT1000cfu/g	90cfulg
Total moulds and yeasts count	NMT100ofu/g	<10cfu/g
Enterobacterial	NMT10clu/g	<10cfu/g
"Escherichia coli	n.d./10g	/
"Salmonella	n.d./10g	1
"Staphylacoccus aureus	n.d./10g	1
Assay	98.5~101.0%	99.9%
Conclusion:This batch complies with the specification of BP2024/USP2024
Report by:                XIONG WENJUAN                                        Approved  by:  王雪迪

2.How it Works?

In the body, it primarily participates in carbohydrate metabolism, acting as a coenzyme in the catalytic reactions of various enzymes. Specifically, thiamine hydrochloride is involved in the oxidative decarboxylation of pyruvate and α-ketoglutarate during glucose metabolism, generating energy for cellular use. Additionally, it plays an important role in maintaining normal nervous system function, particularly in supporting peripheral nerve conduction.

3.Benefits and Use

I. Physiological Functions and Mechanism of Action
Energy Metabolism Regulation
Vitamin B₁ exists in the form of thiamine pyrophosphate (TPP), serving as a coenzyme in key reactions of carbohydrate metabolism (e.g., pyruvate decarboxylation), facilitating the conversion of food into energy (ATP).

Nervous System Support
Maintains the integrity of nerve cell membranes and promotes acetylcholine synthesis, ensuring normal neural signal transmission. Deficiency may lead to peripheral neuritis or cerebral dysfunction.

Cardiovascular Protection
Participates in myocardial energy supply. Deficiency can cause cardiac enlargement, edema, and other manifestations of beriberi heart disease.

II. Deficiency Syndromes and Clinical Manifestations
Dry Beriberi
Primarily characterized by peripheral neuritis, presenting as limb numbness, muscle weakness, and diminished tendon reflexes.

Wet Beriberi
Involves the cardiovascular system, manifesting as palpitations, shortness of breath, and edema, potentially progressing to heart failure in severe cases.

Cerebral Beriberi (Wernicke-Korsakoff Syndrome)
Most commonly observed in chronic alcoholics, symptoms include nystagmus, ataxia, and mental confusion.

III. Primary Clinical Applications
Treatment of Vitamin B₁ Deficiency
Administered orally or via injection to correct deficiency caused by inadequate intake (e.g., long-term polished rice diets), malabsorption (chronic diarrhea), or increased demand (pregnancy, hyperthyroidism).

Adjuvant Therapy for Metabolic Disorders
Used for nutritional support in diabetic peripheral neuropathy, chronic dyspepsia, or patients with hypermetabolic conditions.

Intervention for Alcohol Dependence
Alcohol inhibits B₁ absorption; chronic alcoholics require additional supplementation to prevent brain damage.

4.Q&A

Q:Does the company accept sample orders?

A:Yes, our company accepts sample orders.

Q:What is the minimum order quantity for the company?

A:We do not have a minimum order quantity requirement, we arrange according to the customer's needs.

Q:How to ensure the quality of goods?

A:We have a strict QC/QA management system and strict release procedures, and we will provide all procedures to customers before shipment according to their requirements.

Q:Can we see the product quality before the order is shipped?

A:Of course, we always provide a relative Batach (s) 'COA before shipping.

Q:How will you deliver the goods?

A:We will communicate with customers, adopt their suggestions, arrange the most suitable delivery method, and ensure mutual satisfaction.