1.What is Quercetin?

Quercetin is a naturally occurring flavonoid compound widely found in plants, possessing multiple biological activities including antioxidant, anti-inflammatory, and anticancer properties. Commonly present in foods such as apples, onions, and tea, it is a key focus in dietary supplements and pharmaceutical research.

 

2.How it Works?

Quercetin exhibits multiple mechanisms for combating hyperglycemia, including:

• Enhancing insulin sensitivity

• Promoting glycogen synthesis

• Inhibiting α-glucosidase activity

• Improving insulin resistance

Glucose Metabolism Regulation
By targeting glucose transport and insulin receptor signaling, quercetin:

• Increases glucose uptake in skeletal muscle

• Improves glucose utilization efficiency

Pancreatic β-Cell Protection
In streptozotocin (STZ)-induced diabetic animal models, quercetin:

• Preserves β-cell mass and function

• Enhances serum insulin action

• Elevates plasma insulin levels

• Reduces blood glucose levels

Neuroprotective Effects (Alzheimer's Disease)
Quercetin counters oxidative stress and excitotoxicity by:

• Modulating apoptotic mechanisms

• Overcoming cognitive impairment

• Improving neuronal longevity signaling pathways in AD

In vitro studies reveal:

• The hydroxyl groups on quercetin's B-ring critically inhibit Aβ aggregation

• Forms hydrogen bonds with Aβ β-sheet structures, disrupting mature fibrils

Antiviral Activity (Influenza Virus)
Quercetin interferes with multiple viral lifecycle stages:

• Viral binding and uncoating

• mRNA synthesis and negative-strand synthesis

• Viral assembly and release

In MDCK cell models:

• Cyclic quercetin treatment:

  • Increases cell viability

  • Reduces IAV PA gene expression

  • Lowers total apoptosis and cell death rates

  • Delays viral replication

  • Strengthens cellular defense mechanisms

Hepatoprotective Effects
In chronic alcohol-fed mice, quercetin:

• Alleviates hepatic steatosis

• Enhances lipid clearance capacity

• Reduces liver injury

• Normalizes elevated serum levels of:

  • Triglycerides

  • ALT and AST

 

3.Benefits and Use

1. Antioxidant Effects

• Free radical scavenging: Neutralizes reactive oxygen species (ROS), reducing oxidative stress-induced cellular damage and delaying aging.

• Cellular structure protection: Enhances cell membrane stability and reduces DNA oxidation risk.

2. Anti-Inflammatory Effects

• Inhibition of inflammatory factors: Reduces release of pro-inflammatory cytokines (e.g., TNF-α, IL-6), potentially alleviating chronic inflammation (e.g., arthritis).

• Immune response modulation: Regulates immune cell activity to mitigate excessive inflammatory responses.

3. Cardiovascular Protection

• Vascular function improvement: Stimulates nitric oxide (NO) production, promoting vasodilation and aiding blood pressure regulation.

• Lipid reduction: Inhibits low-density lipoprotein (LDL) oxidation, lowering atherosclerosis risk.

4. Anticancer Potential

• Induction of cancer cell apoptosis: Activates specific signaling pathways to suppress proliferation of certain cancer cells.

• Chemotherapy adjuvant: Preliminary studies suggest it may enhance sensitivity to conventional chemotherapeutic drugs, though research remains ongoing.

5. Metabolic Regulation

• Blood glucose modulation: May slow carbohydrate absorption by inhibiting glycosidase activity, though effects vary individually.

• Fat metabolism promotion: Influences expression of lipolysis-related enzymes, aiding improvement of obesity-related metabolic disorders.

 

4.Q&A

Q:Does the company accept sample orders?

A:Yes, our company accepts sample orders.

Q:What is the minimum order quantity for the company?

A:We do not have a minimum order quantity requirement, we arrange according to the customer's needs.

Q:How to ensure the quality of goods?

A:We have a strict QC/QA management system and strict release procedures, and we will provide all procedures to customers before shipment according to their requirements.

Q:Can we see the product quality before the order is shipped?

A:Of course, we always provide a relative Batach (s) 'COA before shipping.

Q:How will you deliver the goods?

A:We will communicate with customers, adopt their suggestions, arrange the most suitable delivery method, and ensure mutual satisfaction.