1.What is Nicotinamide(Niacinamide)?

Nicotinamide (also known as niacinamide) is the amide compound of nicotinic acid. It appears as a white crystalline powder; odorless or nearly odorless, with a bitter taste; slightly hygroscopic. It is readily soluble in water or ethanol, and soluble in glycerol. Clinically, it is primarily used for the prevention and treatment of pellagra, stomatitis, glossitis, sick sinus syndrome, and atrioventricular block.

 

2.How it Works?

The fundamental principle of nicotinamide lies in its role as a NAD+/NADPH precursor in cellular energy metabolism, coupled with its multi-target regulation of melanin production, transport, and skin barrier function to achieve whitening and anti-aging effects.

Biological Metabolic Principles

1. Coenzyme Synthesis Basis

   • Nicotinamide is a key precursor of NAD+ (Coenzyme I) and NADPH (Coenzyme II), which participate in:

     • Cellular energy metabolism (e.g., TCA cycle)

     • DNA repair

     • Antioxidant reactions

   • Helps maintain normal cellular function.

2. NAD+ Decline Compensation

   • With aging, NAD+ levels decrease, leading to cellular dysfunction.

   • Nicotinamide supplementation delays aging, improving skin laxity and wrinkles.

Skin Action Mechanisms

Whitening Pathways

1. Inhibits Melanin Synthesis

   • Blocks tyrosinase activity, reducing melanin production in melanocytes.

2. Blocks Melanin Transfer

   • Interferes with melanosome transport to the stratum corneum, reducing epidermal pigmentation.

3. Accelerates Metabolism

   • Promotes shedding of pigmented keratinocytes, brightening skin tone.

Anti-Aging & Barrier Repair

1. Antioxidant Effects

   • Reduces free radical damage and neutralizes oxidative stress.

2. Strengthens Skin Barrier

   • Boosts ceramide synthesis, reducing water loss and improving skin smoothness.

 

3.Benefits and Use

(1) An amide derivative of vitamin B3 and a PARP inhibitor.

(2) Biochemical Research: Nicotinamide serves as a nutritional component in tissue culture media. As a clinical drug in the vitamin B complex, it is used for the prevention and treatment of pellagra, stomatitis, glossitis, and related conditions.

(3) Cosmetic Applications:

• In skincare products, it prevents skin roughness, maintains skin cell health, and promotes skin whitening.

• In hair care, it enhances scalp blood circulation, supports healthy hair follicles, promotes hair growth, and prevents baldness.

(4) Interchangeability with Nicotinic Acid:

• Nicotinamide and nicotinic acid are generally interchangeable in most applications.

• Nicotinic acid is converted to nicotinamide in animals.

• Nicotinamide exhibits better water solubility than nicotinic acid but may form lumps by complexing with vitamin C.

• Nicotinamide deficiency causes pellagra, making it effective for pellagra prevention.

(5) Metabolic and Industrial Applications:

• Participates in protein and carbohydrate metabolism, improving nutrition in humans and animals.

• Functions as a nutritional additive in cosmetics.

• Also used in pharmaceuticals, food, and feed additives.

 

4.Q&A

Q:Does the company accept sample orders?

A:Yes, our company accepts sample orders.

Q:What is the minimum order quantity for the company?

A:We do not have a minimum order quantity requirement, we arrange according to the customer's needs.

Q:How to ensure the quality of goods?

A:We have a strict QC/QA management system and strict release procedures, and we will provide all procedures to customers before shipment according to their requirements.

Q:Can we see the product quality before the order is shipped?

A:Of course, we always provide a relative Batach (s) 'COA before shipping.

Q:How will you deliver the goods?

A:We will communicate with customers, adopt their suggestions, arrange the most suitable delivery method, and ensure mutual satisfaction.