Advantages of Biological Fermentation：

Core Differences Between Chemica Synthesis and Biofermentation of AKG/Ca-AKG

	Biofermentation	Chemical Synthesis
Raw Materials	✅Renewable sources	❌ Glutaric acid
Reaction Conditions	✅ Mild conditions	❌ High temperature & pressure
Environmental Impact	✅ Green process	❌ High pollution
Yield & Purity	✅ High yield	❌ Low yield
Equlpment Investment	✅ Lower cost	❌ High-cost
Production Time	✅ 24-72h fermentation cycle	❌ Slow purifcation

What is Ca-AKG?

①Chemical structure and nomenclature：

Chemical formula is Ca(C₅H₅O₅)₂, which is the divalent calcium salt of α-Ketoglutarate.

Features: α-Ketoglutarate is a five-carbon dicarboxylic acid (HOOC-C(=O)-CH₂-CH₂-COOH), containing one ketone group (C=O) and two carboxyl groups (-COOH). The calcium salt form is obtained by the deprotonation of the carboxyl groups followed by binding with Ca²⁺.

② Physical property：

Appearance: White or off-white crystalline powder.

Solubility: It is slightly soluble in water (the solubility of calcium salts is generally lower than that of sodium or potassium salts), and its solubility may increase in acidic environments.

Stability: It is relatively stable to light and heat, but may decompose under strong acidic or alkaline conditions.

③ Chemical property：

Acidity/Alkalinity: As a carboxylate, its aqueous solution exhibits weak alkalinity (pH 7-9).

Reactivity:

Decarboxylation: It may undergo decarboxylation to form succinic acid or carbon dioxide under high temperature or enzymatic catalysis.

Complexing ability: α-Ketoglutarate is a metal chelator and may bind with other metal ions.

Antioxidant property: It indirectly exerts antioxidant effects by scavenging free radicals or participating in the glutathione cycle.

④ Biochemical property：

Tricarboxylic acid cycle (TCA cycle): α-Ketoglutarate is a core intermediate of the TCA cycle, participating in energy metabolism (ATP production) and amino acid synthesis (such as glutamate and glutamine).

Calcium supplementation: Provides biologically available calcium ions, which may support bone health.

Signal regulation: In cells, it participates in regulating the stability of hypoxia-inducible factor (HIF), affecting gene expression and cellular metabolic adaptation.

Why Calcium AKG/Ca-AKG?

① Anti Aging Benefits – Promotes longevity by supporting mitochondrial function

and reducing oxidative stress

②Dual Action Formula – Provides essential calcium+ AKG to support bone strength and cellular health

③Clean Label Ingredient – Produced via fermentation, free from synthetic additives

④ Third-Party Tested – Verified quality and consistency

 

Microbial Test(s)

Code	Test ltem(s)	Unit(s)	Test Method(s)	Test Result(s)
5	Coliforms	CFU/g	FDA/BAM online Chapter 4	<10
6	*Total Plate Count	CFU/g	AOAC 966.23	<10
7	*Total Combined Moldsand Yeasts Count	CFU/g	USP-NF <2021>,officialdate: Official as of 01-Aug2013	<10
8	*Salmonella	/10 g	USP-NF <2022>,officialdate: Official as of 01.Nov-2019	ND
9	Staphylococcus aureus	/10 g	USP-NF<2022>,officialdate: Official as of 01-Nov-2019	ND

 

Chemical Test(s)

Code	Test ltem(s)	Unit(s)	Test Method(s)	Test Result(s)	LOQ
10	Purity of Calcium	%	Q/HHSW 2403S-2024	99.6	-
	alpha-ketoglutarate
	Monohydrate / a-
11	Total Fat(as TG)	g/100 g	AOAC 996.06	0.0129	0.01
12	Moisture	%	AOAC 925.10	0.53
13	pH Value	-	ChP 2020 Volume IV	7.33	-
			General Rule 0631
14	Protein	%	Refer to AOAC 930.29	0.31	-
15	Loss On Drying	%	ChP 2020 Volume IV General Rule 0831	<0.1	-
16	Sodium(Na)	mg/kg	EN 16943:2017	303	10
17	Potassium(K)	mg/kg	EN 16943:2017	ND	30
18	lron(Fe)	mg/kg	EN 16943:2017	ND	3
19	Lead (Pb)	mg/kg	USP<233>elemental impurities-procedures procedure 2USP<233>	0.243	0.05
20	Cadmium(Cd)	mg/kg	USP<233>elemental impurties-procedures procedure 2USP<233>	ND	0.005
21	Arsenic(As)	mg/kg	USP<233>elemental impurities-procedures procedure 2USP<233>	ND	0.005
22	Mercury (Hg)	mg/kg	USP<233>elemental impurities-procedures procedure 2USP<233>	ND	0.003
23	Calcium ion content	%	Q/HHSW 2403S-2024	19.9	-
24	Crude ash	%	AOAC 923.03	49.1	-

Q&A

Q:Does the company accept sample orders?

A:Yes, our company accepts sample orders.

Q:What is the minimum order quantity for the company?

A:We do not have a minimum order quantity requirement, we arrange according to the customer's needs.

Q:How to ensure the quality of goods?

A:We have a strict QC/QA management system and strict release procedures, and we will provide all procedures to customers before shipment according to their requirements.

Q:Can we see the product quality before the order is shipped?

A:Of course, we always provide a relative Batach (s) 'COA before shipping.

Q:How will you deliver the goods?

A:We will communicate with customers, adopt their suggestions, arrange the most suitable delivery method, and ensure mutual satisfaction.