1.What is Berberine Hcl?

Berberine Hydrochloride is an organic compound with the chemical formula C₂₀H₁₈ClNO₄. It appears as a yellow crystalline powder with the following solubility properties:

• Easily soluble in boiling water

• Slightly soluble in cold water

• Nearly insoluble in cold ethanol, chloroform, and ether

Pharmacological Applications

Primarily used as an antibacterial agent, it inhibits:

• Dysentery bacilli

• Escherichia coli

• Pneumococci

• Staphylococcus aureus

• Streptococci

• Typhoid bacilli

• Amoeba protozoa

Clinical Use: Mainly treats intestinal infections and bacillary dysentery.

 

2.How it Works?

Core Mechanism of Berberine Hydrochloride

The primary action mechanism of berberine hydrochloride involves broad-spectrum antibacterial effects through:

• Disruption of bacterial DNA replication

• Inhibition of protein synthesis

It also exhibits multiple pharmacological properties, including:

• Anti-inflammatory effects

• Gut microbiota modulation

• Potential hypoglycemic activity

 

3.Benefits and Use

1. Inhibition of Bacterial DNA Replication and Metabolism

   • Berberine hydrochloride disrupts bacterial DNA replication, blocking genetic material synthesis.

   • Simultaneously inhibits bacterial protein production, suppressing or killing:

     • Gram-positive bacteria (e.g., Staphylococcus aureus, Streptococcus hemolyticus)

     • Gram-negative bacteria (e.g., Shigella dysenteriae, Escherichia coli).

2. Destruction of Bacterial Structure

   • Studies show it reduces bacterial fimbriae, impairing host cell adhesion and weakening pathogenicity.

Additional Pharmacological Effects

3. Anti-Inflammatory and Antidiarrheal Actions

   • Alleviates intestinal mucosal inflammation and reduces luminal secretions, improving infectious diarrhea symptoms.

4. Gut Microbiota Modulation

   • Suppresses pathogenic bacteria while promoting probiotic growth, restoring microbial balance.

5. Potential Hypoglycemic Effects

   • Recent research suggests it may improve insulin sensitivity to regulate glucose metabolism, though not yet a routine clinical application.

 

4.Q&A

Q:Does the company accept sample orders?

A:Yes, our company accepts sample orders.

Q:What is the minimum order quantity for the company?

A:We do not have a minimum order quantity requirement, we arrange according to the customer's needs.

Q:How to ensure the quality of goods?

A:We have a strict QC/QA management system and strict release procedures, and we will provide all procedures to customers before shipment according to their requirements.

Q:Can we see the product quality before the order is shipped?

A:Of course, we always provide a relative Batach (s) 'COA before shipping.

Q:How will you deliver the goods?

A:We will communicate with customers, adopt their suggestions, arrange the most suitable delivery method, and ensure mutual satisfaction.