1.What is Alpha Lipoic Acid?

Lipoic Acid (Alpha Lipoic Acid) is a water- and fat-soluble metabolic antioxidant, a vitamin-like substance. α-Lipoic acid appears as a light yellow crystalline powder with almost no odor. It has low solubility in water (~1 g/L at 20°C), dissolves in 10% NaOH solution and aliphatic solvents, and is readily soluble in methanol, ethanol, chloroform, and ether.

Lipoic acid is also referred to as α-lipoic acid.

1. Chirality

   • Lipoic acid contains one chiral center, thus existing in R- and S-configurations.

   • Naturally occurring lipoic acid is a white crystal exclusively in the R-configuration.

   • Only R-lipoic acid can covalently conjugate to lysine residues via amide bonds to exert coenzyme functions.

2. Synthetic Form

   • Artificially synthesized lipoic acid consists of a 1:1 mixture of R- and S-configurations.

   • It presents as a light yellow powder with high solubility in lipid solvents.

 

2.How it Works?

Lipoic Acid Properties and Applications

1. Free Radical Scavenging

   • Lipoic acid exhibits potent free radical scavenging capabilities, with an efficacy over 100 times greater than vitamin C, making it particularly suitable for anti-aging products.

   • It functions as a metal chelator, binding to copper ions in tyrosinase and acting as a competitive inhibitor, thereby delivering significant skin-whitening effects.

2. Limitations of Conventional Lipoic Acid

   • Poor solubility

   • Low stability

   • Strong odor
     These drawbacks restrict its application in cosmetics.

3. Solution: Lipoic Acid-Cyclodextrin Inclusion Complex
   Complexing lipoic acid with cyclodextrin effectively addresses these limitations.

 

3.Benefits and Uses

 

Antioxidant Effects
α-Lipoic acid reduces cellular damage from free radicals by inhibiting lipid peroxidation. It scavenges various free radicals in the body, including hydroxyl radicals (-OH), nitric oxide radicals (NO·), and peroxynitrite (ONOO·), as well as hydrogen peroxide (H₂O₂) and hypochlorous acid (HClO), which are prone to generate free radicals.

Additionally, α-lipoic acid is converted intracellularly to its reduced form, dihydrolipoic acid (DHLA). Both are potent antioxidants capable of simultaneously neutralizing reactive oxygen species (ROS) and reactive nitrogen species (NO, NO·).

Lipid Regulation Effects
α-Lipoic acid can modulate blood lipid levels by reducing triglycerides or cholesterol. Under medical supervision, it aids in lowering blood lipids and preventing cardiovascular diseases.

Microcirculation Improvement
α-Lipoic acid exhibits vasodilatory properties, enhancing local blood circulation and alleviating symptoms like limb numbness. This mechanism makes it highly effective in improving microcirculation.

Other Mechanisms

1. Anti-inflammatory Action:

   • Prevents catalytic effects of heavy metal ions (Cu²⁺, Fe²⁺, Hg²⁺) in oxidative processes, thereby inhibiting free radical formation.

2. Metabolic Role:

   • As an acyl carrier, it participates in the tricarboxylic acid (TCA) cycle, facilitating pyruvate breakdown and improving glucose utilization.

 

4.Q&A

Q:Does the company accept sample orders?

A:Yes, our company accepts sample orders.

Q:What is the minimum order quantity for the company?

A:We do not have a minimum order quantity requirement, we arrange according to the customer's needs.

Q:How to ensure the quality of goods?

A:We have a strict QC/QA management system and strict release procedures, and we will provide all procedures to customers before shipment according to their requirements.

Q:Can we see the product quality before the order is shipped?

A:Of course, we always provide a relative Batach (s) 'COA before shipping.

Q:How will you deliver the goods?

A:We will communicate with customers, adopt their suggestions, arrange the most suitable delivery method, and ensure mutual satisfaction.